摘要
脑功能磁共振成像(fMRI)最主要的形式是血氧水平依赖磁共振成像(】BOLD-fMRI),根据神经元兴奋后局部氧耗与血流增幅不一致,用BOLD效应机制成像,间接显示神经元活动。BOLD-fMRI通过静息态和任务态两种模式,对精神疾病的研究已经不仅局限于研究特定脑区激活程度的差异,更逐渐关注分析各脑区间的神经环路和功能网络连接的变化。本文综述BOLD-fMRI成像原理、应用模式及在研究精神分裂症等常见精神障碍疾病脑区神经活动的相关性及功能连接。
Blood oxygen level-dependent magnetic resonance imaging(BOLD-fMRI) is one of the most important methods of functional fMRI. Based on the BOLD principle, arterial oxygenated blood would be redistributed and moved to the objective brain area. The analysis of resting-state and task-state fMRI, not only reflects the activated signal in specific brain region, but also shows the brain functional connectivity network and connection relations. This article reviewd the principle, techniques, and future application of BOLD-fMRI in mental disorders.
出处
《解剖科学进展》
2016年第1期87-91,共5页
Progress of Anatomical Sciences
基金
国家自然科学基金(81271499)