树突状细胞相关受体在烟曲霉感染中作用的研究现况

Research on the current situation of dendritic cell related receptors' role in Aspergillus fumigatus infection

烟曲霉是一种条件致病菌,一旦感染免疫抑制的患者,其病死率高达60%～80%。树突状细胞（DC）为专职的抗原递呈细胞,是连接固有免疫和适应性免疫的桥梁,可通过不同的受体识别烟曲霉的孢子及菌丝,在吞噬病原菌后分泌相应的致炎因子并调节Th细胞的成熟和分化,进而有效地抵御烟曲霉的感染。因此,DC受体在这一过程中起着关键作用,文章将对DC相关受体在烟曲霉感染中作用的研究现况进行综述。

Aspergillusfumigatus is a kind of opporunistic pathogens, and once the infection occurs in patients with immunosuppression, the fatality rate is as high as 60%-80%. As a kind of full-time antigen presented cells, dendritic cells （ DC ） connect inherent immunity and adaptive immunity. They can recognize different spores and hyphae of Aspergillus fumigatus by their receptors, and secrete corresponding inflammatory factor after consuming pathogenic bacteria to adjust the maturation and differentiation of Th cells and thereby effectively resist Aspergillus fumigatus infection at last. So DC receptors may play a key role in this process, and this review focuses on the DC related receptors＇ role in Asperzillus fumieatus infection.