石墨炉原子吸收光谱法测定酒石酸唑吡坦原料药中的痕量钯

Determination of Trace Platinum in Zolpidem Tartrate by GFAAS

目的：建立测定酒石酸唑吡坦原料药中痕量钯的方法。方法：采用石墨炉原子吸收光谱法,样品用1%盐酸溶液溶解后直接测定。采用横向平台石墨管,检测波长为244.79 nm,光谱带宽为0.2 nm,空心阴极灯工作电流强度为6 m A,扣背景方式为塞曼效应,测量模式为峰高,进样量为20μl。结果：钯的检测质量浓度线性范围为0~100 ng/ml（r=0.999 0）;精密度、重复性试验的RSD≤2.0%;加样回收率为97.78%~103.07%,RSD=1.6%（n=9）;检测限为1.48 ng/ml。结论：该方法操作简便、迅速,具有良好的精密度和准确度,可用于酒石酸唑吡坦原料药中痕量钯的测定。

OBJECTIVE：To establish a method for determination of trace platinum in zolpidem tartrate. METHODS：Graphite furnace atomic absorption spectrometry（GFAAS）was adopted for direct determination after dissolving sample in 1% Hydrochloric acid solution. Horizontal platform graphite tube was performed with detection wavelength of 244.79 nm,slit width of 0.2 nm and current intensity of hollow cathode lamp of 6 m A. The mode of background correction was zeeman effect,the peak height was used as measurement pattern,and the injection volume was 20 μl. RESULTS：The linear range of platinum was 0-100 ng/ml（r=0.999 0）;RSDs of precision and reproducibility tests were no more than 2.0%;recovery was 97.78%-103.07%（RSD=1.6%,n=9）;the detection limit was 1.48 ng/ml. CONCLUSIONS：This method is simple and rapid with good precision and accuracy,and can be applied for the determination of trace platinum in zolpidem tartrate.