VEGFR-3mRNA在乳腺癌中的表达及临床意义

Expression and clinical significance of VEGFR- 3 mRNA in breast cancer

目的:探讨血管内皮生长因子受体3 mRNA(vascular endothelial growth factor receptor 3,VEGFR-3)在乳腺癌中的表达及临床意义。方法:用逆转录聚合酶链反应(reverse transcription polymerase chainreaction,RT-PCR)法检测60例乳腺浸润性导管癌中VEGFR-3 mRNA的表达,取15例乳腺纤维腺瘤标本作对照。结果:乳腺癌组VEGFR-3 mRNA阳性表达率及表达程度明显高于对照组,有统计学差异(P<0.01)。乳腺癌淋巴结转移阳性组VEGFR-3 mRNA表达率及表达程度高于淋巴结转移阴性组(P<0.05),VEGFR-3mRNA的表达与乳腺癌腋淋巴结转移呈正相关(r=0.704,P<0.05)。不同肿块大小、病理分期等临床病理指标分组中VEGFR-3 mRNA表达无显著性差异(P>0.05)。结论:乳腺癌组织中VEGFR-3 mRNA表达水平增高,VEGFR-3在乳腺癌淋巴结转移中发挥重要作用。

Objective： To study the expression and clinical significance of VEGFR- 3 mRNA in breast cancer.Methods： RT- PCR was adopted in detecting the VEGFR- 3 mRNA expressions in 60 cases of breast cancer. Take15 cases of breast fibroadenoma as control. Results： The positive ratio and degree of VEGFR- 3 mRNA in breast cancer was higher than the control group. VEGFR- 3 mRNA was conspicuously higher in lymph- node- positive group than in lymph- node- negative group. The expression of VEGFR- 3 mRNA was positively correlated with axillary lymph node metastasis. There were no statistically significant differences in pathologic features,tumor size and clinical stage. Conclusion： The expression of VEGFR- 3 mRNA was higher in breast cancer,and it played an important role in the lymph node metastasis.