广西崇左HBsAg阳性人群CYP3A5的基因多态性

A study on gene polymorphism of CYP3A5 of the HBs Ag- positive population in Chongzuo city,Guangxi Procince

目的:探讨HBs Ag阳性人群中CYP3A5基因多态性与肝癌遗传易感性的关系。方法:通过癌症筛查发现广西崇左市HBs Ag阳性人群,选取肝癌家族HBs Ag阳性成员109例(研究组)及与之相对应的无肿瘤家族HBs Ag阳性成员109例(对照组)作为研究对象,用PCR-RFLP法检测CYP3A5基因。结果:研究组AA基因型的分布与对照组有显著性差异(P<0.05)。研究组A等位基因的分布与对照组有显著性差异(P<0.05)。结论:CYP3A5基因多态性与肝癌的遗传易感性密切相关。

Objective： To discuss the relationship between the CYP3A5 gene polymorphism of the HBs Ag- positive population and the genetic susceptibility of liver cancer. Methods： The HBs Ag- positive population was identified via cancer screening in Chongzuo City,Guangxi Province. Among them 109 HBs Ag- positive cases（ the subject group） with a family history of hepatoma and 109 HBs Ag- positive cases（ the control group） without a family history of hepatoma as the subjects were choosed. Their CYP3A5 gene was tested with PCR- RFLP. Results： Significant difference（ P〈 0. 05） was found in the subject group＇s AA genetype distribution and the control group ＇s. Significant difference（ P〈 0. 05） of A allelic distribution was also identified between the subject group and the control group.Conclusion： There is a close link with the CYP3A5 gene polymorphism and the genetic susceptibility of liver cancer.