前列腺钬激光剜除术与汽化电切术对患者血PSA的影响

CLINICAL STUDY OF PROSTATE HOLMIUM LASER ENUCLEATION AND TRANSURETHRAL OPERATION ON BLOOD PSA

目的探讨前列腺的两种腔内手术的方法对血PSA临床变化的影响。方法选取前列腺剜除术和前列腺汽化电切术共286例患者,均在术后3d拔出尿管的患者,对其术前,术后3d,术后1周,1个月,3个月PSA变化进行分析及随访,并行统计学分析。结果血PSA在钬激光组中和电切组中术后3d均不同程度的增高,术后一周逐渐下降,钬激光组下降明显,经统计学分析二组P<0.01,差异有统计学意义;术后1个月降至最低值,钬激光组下降的程度比电切组明显,3个月变化不大,差异无统计学意义(P>0.05)。结论钬激光剜除术与电切术均是前列腺腔内手术的两种方法,剜除术可以使血PSA下降较快,并较长时间持续低水平,明显优于电切术,剜除术切除前列腺更彻底。疗效更佳。

Objective To review the effect of prostate analysis of two kinds of endoscopic surgery on clinical changes of serum prostate specific antigen（PSA）.Methods A total of 286 cases of patients with enucleation of the prostate and transurethral vaporization and electro resection were selected as the research subjects.All patients with postoperative three days pulled out the catheter,and the changes of PSA were analyzed and followed up before operation,after three days,one week after operation,January,March respectively.Results Blood PSA was increased in the holmium laser group and the electric cutting group in three days after the surgery,then they decreased significantly at one week after the surgery,and more obviously decreased in the holmium laser group was found than the the electric cutting group,moreover,they were reach to the lowest value at one month after the surgery,the difference was statistically significant（P〈0.01）.But the degree of holmium laser group was no significantly less than that of the electric cutting group at three months after the surgery（P〉0.05）.Conclusions Holmium laser enucleation and electric cut operation are two methods of transurethral surgery,the former can make blood PSA decline faster,and the longer the time continuous low level,obviously superior to electric resection and enucleation resection of the prostate more thoroughly.