IL-33/ST2对慢性阻塞性肺疾病肺动脉高压形成的影响

Effect of IL-33/ST2 on the Formation of Pulmonary Arterial Hypertension in Chronic Obstructive Pulmonary Disease

目的:研究慢性阻塞性肺疾病(COPD)患者血液及痰液IL-33/sST2水平与COPD肺动脉高压形成的关系。方法:将确诊COPD急性加重期的31例患者,依心脏彩超结果分为COPD伴肺动脉高压组(COPD-PAH)和COPD不伴肺动脉高压组(COPD-non PAH),取血液及痰液标本,ELISA法检测IL-33、sST2和IL-6,并进行多因素Logistic分析。25例健康志愿者为对照组(HC)。结果:1COPD-PAH组血清sST2水平显著高于COPD-non PAH组(P<0.05),两组血清IL-33、IL-6和痰液IL-33、sST2、IL-6水平无统计学差异。两组间多因素Logistic分析仅PaO2进入方程。2COPD-PAH组血清IL-33、sST2和IL-6水平显著高于HC组(P<0.05);COPD-non PAH组血清IL-33和IL-6水平显著高于HC组(P<0.05),但血清sST2水平与HC组无统计学差异。结论:IL-33、sST2、IL-6参与COPD的气道及全身炎症过程。sST2可能参与COPD-PAH形成的炎症机制。

Objective： To explore the correlation of IL-33/ST2 and the formation of pulmonary arterial hypertension （PAH） in chronic obstructive pulmonary disease （COPD）. Methods： Thirty pa- tients diagnosed with AECOPD were recruited. The COPD patients were divided into COPD- PAH group （13 cases） and COPD-non PAH group （18 cases） according to the result of echocar- diography. The samples of blood and sputum were collected. The result of pulmonary function test, blood gas analysis and other clinical index of COPD patients were collected. Healthy volun- teers （25 cases） were enrolled as healthy control group （HC）. Concentrations of IL-33, sST2, and IL-6 in serum and sputum samples were detected by ELISA. The multi-factorial logistic anal- ysis was done. Results： The serum level of sST2 in COPD-PAH group was higher than that in COPD-non PAH group （P〈0.05）. No significant difference was found in serum IL-33, IL-6 or the sputum levels of sST2, IL-33 or IL-6 between the two groups. The multi-factorial logistic a- nalysis found that only the PaO2 was in the regression equation between these two groups. @COPD-PAH group had higher levels of serum IL-33, sST2 and IL-6（P〈0.05）. As compared with HC, COPD-non PAH group had higher levels lar levels of serum sST2. Conclusion： IL-33, sST2 of serum IL-33 and IL-6（P〈0.05）, but simi and IL-6 were involved in the chronic inflam matory process of COPD. The elevation of sST2 in serum was associated with the formation of PAH in COPD.