EB病毒相关的结外鼻型NK/T细胞淋巴瘤研究进展

The Research Progress of Extranodal Nasal Type NK / T-cell Lymphoma Associated with Epsteinbarr Virus

结外鼻型自然杀伤(NK)细胞/T细胞淋巴瘤(ENKTL)为罕见的非霍奇金淋巴瘤。EB病毒的感染能表达一系列潜伏蛋白,且此类蛋白的表达与ENKTL的发病密切相关,但EB病毒引起T细胞及NK细胞淋巴增殖性疾病的确切机制目前仍未知。针对EB病毒相关的恶性肿瘤最有效的治疗方案是以丁酸类药物人工诱导肿瘤细胞的EB病毒基因达裂解期,再联合抗病毒药物作用于肿瘤细胞为基础的联合疗法。

Extranodal NK/T-cetl lymphoma, nasal type（ ENKTL）, is a rare type of non-Hodgkin＇s lymphoma. Researches proved that a series of latent proteins could be expressed with infection of EB virus ,which are closely related to the pathogenesis of ENKTL. However, our understanding of EBV＇s contribution to the pathogenesis of T and NK lymphoproliferation is still limited. The current study showed that the most significant advancement in virus-targeted therapies for EBV malignancies is undoubtedly the combination therapy based on artificial induction of EBV lyticphase gene expression till risephase, followed by exposure of the tumor cells to anti-herpes virus drugs.