细胞周期调控与肿瘤发生和治疗的关系研究

Relation of cell cycle regulation with occurrence and treatment of tumor

在细胞周期运转过程中,有多种蛋白、复合物和细胞周期检测点等复杂物质的参与,这些物质共同调节并控制着细胞周期的运转过程.这些物质中的一种或几种产生变化,都会导致细胞周期无法向下正常转换,扰乱并使细胞周期失常,引起细胞不受控地增殖.而对参与细胞周期运转的相关蛋白进行调控,能够使肿瘤细胞的活性得到抑制,并进一步阻滞了肿瘤细胞的无限增殖,达到治疗肿瘤的目的.

In the process of cell cycle operation, many proteins, complexes and cell cycle checkpoints are involved in, which adjust and control the running process of the cell cycle together. If one or several of these material changes, a normal transformation of cell cycle will not be obtained, and cell cycle will be disrupted and disordered causing cell proliferation not controlled. By adjusting and controlling operation involved in cell cycle related proteins, the activity of tumor cells can be suppressed. The infinite proliferation of cancer cells can be further blocked achieve the goal of treatment of tumor.