期刊文献+

利妥昔单抗对免疫性血小板减少症的治疗价值分析

下载PDF
导出
摘要 目的:分析利妥昔单抗对免疫性血小板减少症的临床应用价值。方法:选取2008年1月-2014年12月我院收治的50例免疫性血小板减少症患者为研究对象,将其随机分为A组与B组各25例。A组给予小剂量利妥昔单抗治疗,B组给予标准剂量利妥昔单抗治疗,比较2组患者的临床治疗效果。结果:2组患者总有效率比较无明显差异(P〉0.05);治疗后,2组患者PLT(血小板)与CD19^+淋巴细胞数与治疗前比较,差异显著有统计学意义(P〈0.05);但组间比较,无明显差异(P〉0.05)。且2组患者不良反应发生率比较,无明显差异(P〉0.05)。结论:不同剂量的利妥昔单抗治疗免疫性血小板减少症的临床效果均较为理想,值得在临床上推广。
作者 高继勇
出处 《中国伤残医学》 2016年第3期120-121,共2页 Chinese Journal of Trauma and Disability Medicine
  • 相关文献

参考文献5

二级参考文献37

  • 1李文莲,李光贵.不同剂量静脉免疫球蛋白治疗极重度ITP疗效分析[J].遵义医学院学报,2010,33(6):580-582. 被引量:2
  • 2Go RS,Johnston KL,Bruden KC. The association between platelet autoantibody specificity and response to intravenous immunoglobulin G in the treatment of patients with immune thrombocytopenia.Haematologica.2007,Feb;92(2):283-284.
  • 3George J N, Raskob G E. Idiopathic thrombocytopenic purpura: diagnosis and management [J]. Am J Med Sci, 1998, 316(2) : 87-93.
  • 4British Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thmmboeytopenic purpura in adults, children and in pregnancy [J]. Br J Haematol,2003,120(4): 574-596.
  • 5Zaja F, Marin L, Chiozzotto M, et al. Dapsone salvage therapy for adult patients with immune thromboeytopenia relapsed or refractory, to steroid and rituximab [J ]. Am J Hematol,2012,87 (3) :321-323.
  • 6Arnold D M, Heddle N M, Carruthers J, et al. A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia [J ]. Blood, 2012, 119(6) : 1356-1362.
  • 7Zaja F, Vianelli N, Volpetti S, et al. Low-dose rituximab in adult patients with primary immune thrombocytopenia [Jl. Eur J Haematol, 2010,85 (4) : 329-334.
  • 8Cervinek L, Cernt O, Canigu M, et al. Efficacy of rituximab in primary immune thrombocytopenia:an analysis of adult pretreated patients from everyday hematological practice [J]. lnt J Hematol, 2012, 96(5) :594-599.
  • 9Zaja F, Volpetti S, Chiozzotto M, et al. Long-term follow-up analysis after rituximab salvage therapy in adult pa-tients with immune thrombocytopenia[J]. Am J Hematol,2012,87(9)-886-889.
  • 10Patel VL,Mahevas M,Lee SY,et al. Outcomes 5 years af-ter response to rituximab therapy in children and adultswith immune thrombocytopenia[J]. Blood,2012,119(25):5989-5995.

共引文献37

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部