山莨菪碱在小儿脓毒性休克治疗中的疗效观察

Effect of anisodamine in children with septic shock in the treatment of observation

目的:探讨山莨菪碱在小儿脓毒性休克中的治疗效果。方法:选取我院收治的40例脓毒性休克患儿随机分为观察组和对照组,对照组采用常规治疗,观察组在对照组治疗基础上加用山莨菪碱治疗,比较两组治疗效果、给药24h后平均动脉压(MAP)、中心静脉压(CVP)和心率,统计两组患儿复苏时间和复苏时胃黏膜动脉血二氧化碳分压差[P(g-a)CO2]。结果:观察组治疗总有效率为100.00%明显高于对照组的70.00%,差异有统计学意义(P<0.05);观察组用药24h后MAP、CVP、心率明显高于对照组,差异有统计学意义(P<0.05);观察组复苏时间和复苏时P(g-a)CO2值明显小于对照组,差异有统计学用药(P<0.05)。结论:山莨菪碱治疗小儿脓毒性休克可改善患儿血液灌注,缩短复苏时间,提高治疗效果,但可引起患儿心率加快,临床用药应引起重视。

Objective：To study the effect of anisodamine in children with septic shock treatment effect. Method：Methods in our hospital treated 40 patients with septic shock were randomly divided into observation group and control group, the control group with conventional treatment,the observation group in the control group treatment based on adding anisodamine treatment,the effect of treatment in the two groups were compared,to mean arterial pressure after 24h（MAP）,central venous pressure（CVP）and heart rate,statistical time two groups of children with recovery and recovery of arterial blood in gastric mucosal p CO2,[P（G-A）CO2]. Result：The observation group with an effective rate of 95.00% was significantly higher than the control group total effectiveness 80.00%,two groups was statistically significant（P0.05）; the observation group 24 h after administration of MAP,CVP,heart rate was significantly higher than the control group,the values between the two groups were statistically significant（P0.05）; the observation group with the recovery time and recovery of P（G-A）CO2values were significantly lower than that of control group,the two groups were statistically use values（P 0.05）. Conclusion：Anisodamine in the treatment of pediatric septic shock patients can improve blood perfusion,shorten the recovery time,improve the therapeutic effect,but children can cause increased heart rate,clinical medication should pay attention to.