6Mundargi R C, Srirangarajan S, Agnihotri S A, et al. Development and evaluation of novel biodegradable microspheres based on poly( D, L-lactide-co-glycolide) and poly ( epsilon-caprolactone ) for controlled delivery of doxycycline in the treatment of human periodontal pocket:In vitro and in vivo studies [ J ]. J Controlled Release ,2007,119 (1) : 59-68.
7Caton J, Ryan M E. Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD) [J]. Pharmacol Res,2011,63(2) :114 -20.
8孟焕新.牙周病学[M].3版.北京:人民卫生出版社,2009:119-24.
9Southard G L, Godowski K C. Subgingival controlled release of antimicrobial agents in the treatment of periodontal disease [ J ]. Int J Antimicrob Agents , 1998,9 (4) :239 - 53.