32例耐药结核性脑膜炎的疗效及预后分析

Analysis of the Curative Effect and Prognosis of 32 Cases of Drug Resistant Tuberculosis Meningitis

目的分析耐药结核性脑膜炎(TBM)的疗效及预后。方法对2010年1月-2015年12月住院的32例成人耐药TBM患者病历资料进行回顾性分析并电话随访了解患者的预后情况,采用改良Rankin量表(m RS)对预后进行评分。结果 32例耐药TBM患者中好转31例(96.9%),治疗无效死亡1例(3.1%)。治疗后1例出现激素相关性青光眼及骨质疏松,1例出现药物性库欣综合征。27例(84.4%)患者m RS评分≤2分。结论耐药TBM早期诊断困难,经积极抗结核并辅助治疗,疗效满意。

Objective To analyze the curative effect and prognosis of drug resistant tuberculosis meningitis（TBM）. Methods Retrospective analysis was carried out on the clinical data of thirty-two cases of drug resistant tuberculous meningitis patients hospitalized from January 2010 to December 2015. And the prognosis of the patients was evaluated by meliorated Rankin Scale（m RS）. Results Thirty-one cases（96.9%） were improved in 32 patients with drug resistant TBM, and 1 case（3.1%） was ineffective. After treatment, one patient had hormone-related glaucoma and osteoporosis, and one patient had drug Cushing syndrome. Twenty-seven patients（84.4%） had an m RS score equal to or less than 2 points. Conclusion Drug resistant TBM is difficult to diagnose in the early stage, and the curative effect is satisfying with active anti-tuberculosis treatment.