摘要
蛋白质组学(proteomics)作为一种大规模研究细胞蛋白质功能的重要技术和研究方法,广泛应用在揭示肿瘤发病分子机制、寻找生物标志物、筛选治疗新药物等方面。植物多酚作为一种天然活性物质,已经证实具有抗肿瘤潜力。本文对蛋白质组学及运用蛋白质组学技术和研究方法探讨植物多酚抗肿瘤作用机制进行了综述,以期为植物多酚保健食品、药品的开发提供一定的科学依据。
Proteomics, an important method for the large-scale study of cellular proteins, has been widely used for exploring the molecular mechanisms of cancer, searching for biomarkers, and screening for new anticancer drugs. The antitumor potential of plant polyphenols, as natural active substances, has been confirmed. This paper provides an overview of proteomics and reviews recent progress in proteomic studies of the antitumor mechanisms of plant polyphenols, aiming to provide a scientifi c basis for the application of plant polyphenols in health food and drugs.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2016年第3期235-240,共6页
Food Science
基金
国家自然科学基金面上项目(31471576)
"十二五"国家科技支撑计划项目(2013BAD16B01)
关键词
植物多酚
蛋白质组学
抗肿瘤
分子机制
plant polyphenols
proteomics
antitumor
molecular mechanism
