摘要
目的:报道1例罕见的初诊为t(15;17)的急性早幼粒细胞白血病复发后演变成ins(17;15)的病例,并探讨其临床和实验室特点。方法:骨髓细胞经直接法和24h培养法制备染色体标本,以R显带技术进行核型分析;采用染色体15号和17号位点特异双色双融合PML/RARa基因探针进行荧光原位杂交。结果:该患者初诊时染色体核型分析结果为t(15;17)(q22;q12),荧光原位杂交结果显示2红2绿1融合(2R2G1F)的异常信号。经诱导化疗及巩固治疗后,达到完全缓解,但是1年后复发,核型演变成ins(17;15)(q12;q14q22),7个月后又第2次复发。结论:ins(17;15)可以从t(15;17)的核型演变而来,可能提示病情恶化,预后不佳。
Objective：To report an acute promyelocytic leukaemia（APL）case with t（15;17）karyotype evolving into ins（17;15）after relapse,and review its clinical and laboratory characteristics.Method：Chromosome specimens were prepared using direct method or 24 hculture of bone marrow cells.R-banding technique was used to analyze karyotypes.Fluorescence in situ hybridization（FISH）analysis was performed using chromosome 15 and 17site specific dual fusion PML/RARa gene probe.Result：The patient’s chromosome karyotype at initial diagnosis was t（15;17）（q22;q12）and FISH results showed abnormal signal of 2R2G1 F.The patient received induction and consolidation therapy after complete remission,but karyotype evolved into ins（17;15）（q12;q14q22）when he relapsed after 1year and second relapsed 7months later.Conclusion：Ins（17;15）can evolve from t（15;17）,which may indicate deterioration and poor prognosis of the disease.
出处
《临床血液学杂志》
CAS
2016年第1期55-56,共2页
Journal of Clinical Hematology
