甘露聚糖结合凝集素的研究进展

Progress in Research on Mannan-binding Lectin

甘露聚糖结合凝集素(MBL)是一种肝源性血清糖蛋白,属于C型凝集素超家族成员中一种胶原凝集素,在天然免疫中起重要作用。MBL具有调理功能,可选择性结合表面富含甘露寡糖的病原体,既可通过MBL途径激活补体,也可特异性结合细胞表面受体活化巨噬细胞介导调理吞噬作用。已发现MBL基因突变可致血清MBL水平低下和功能缺损。MBL缺损使个体易患某些感染性疾病和自身免疫病。现综述近些年来对MBL的研究进展,尤其是在合并其他免疫缺陷时的研究进展,并探讨MBL的研究展望。

Marman-binding leetin（MBL） is a serum protein of hepatic origin belonging to collectin family and plays an important role in innate immune defense. MBL may act as an opsonin activating complement through binding selectively to mannan - rich pathogens and also activates macrophages via recognizing specific cell receptors. It is found that MBL gene mutations may induce low serum concentration and functional defect of MBL. The individuals with MBL deficiency are susceptible to some infections and autoimmune diseases.