斯钙素在肾细胞癌发病机制中的作用研究进展

Research advance in the role of stanniocalcin in the pathogenesis of renal cell carcinoma

肾细胞癌(renal cell carcinoma,RCC)是泌尿系统最致命的恶性肿瘤之一,其发病机制尚不清楚。斯钙素(stanniocalcin,STC)是一类具有多种生物学功能的糖蛋白激素。近年来,STC在肿瘤发病中作用日益受到重视,其中STC在肾细胞癌发病机制中作用研究已成为当前该领域研究的热点之一。文中从STC诱导肿瘤细胞适应低氧环境、促进肿瘤新生血管形成、促进肿瘤细胞增殖与凋亡、侵袭与转移以及抑制免疫反应几个方面,阐述STC在肾细胞癌发病机制中的作用,并对其相关研究进展作一综述,旨在为STC成为肾细胞癌诊断的标记物和靶点提供依据。

Renal cell carcinoma（ RCC） is one of the most lethal malignancies of the urinary system,however,its pathogenic mechanism is not clear. Stanniocalcin（ STC） is a type of glycoprotein hormone with multiple biological functions. Recently,the role of STC in the pathogenesis of cancer is of intriguing interest,and many researches have been performed to clarify underlying mechanism.We emphasized the role of STC in the underlying mechanism of RCC progression,from the aspects of STC inducing hypoxia adaptation of tumor cells,promoting tumor angiogenesis,also promoting cell proliferation,apoptosis,invasion and metastasis,and inhibiting the immune response. Conclusively,STC could be used as both a promising biomarker for RCC diagnosis and a theraputic target of renal cell carcinoma.