成纤维细胞在心房纤颤发生中的作用机制

Role of fibroblasts in the development of atrial fibrillation

心肌成纤维细胞在各种致病因素的作用下,转化为肌成纤维细胞并过度增殖,同时产生过量的细胞外基质(extracellular matrix,ECM)蛋白,这一过程涉及一系列复杂的信号通路及电生理机制,可导致心房纤维化的发生,并引起心房在结构、功能、电生理方面的重构,而心房重构是心房纤颤动发生最重要的过程之一。文中就成纤维细胞在心房纤维化、心房重构、心房纤颤发生中的作用作一综述。

Influenced by a variety of pathologic factors,cardiac fibroblasts can transdifferentiate into myofibroblasts and proliferate excessively,followed by an overdue secretion of extracellular matrix（ ECM）. This process involves complicated signaling pathways and electrophysiological mechanisms and may result in atrial fibrosis and contribute to atrial remodeling in structure,function and electrophysiological signaling,which is considered as a most important phase of atrial fibrillation. This review focuses on the role of fibroblasts in atrial fibrosis,atrial remodeling,and the development of atrial fibrillation.