IL-21、IL-22在子痫前期患者血清表达的研究

The study of the expression of IL-21 and IL-22 in serum of patients with preeclampsia

目的通过检测子痫前期患者与正常孕妇血清IL-21、IL-22的表达水平,为子痫前期发病及诊断提供新的思路。方法选取2014年4~8月山西医科大学第一医院产科入院的子痫前期患者轻度组23例和重度组30例,分别与同期产前检查正常的晚期妊娠妇女30例作对照组。采用ELISA方法检测三组血清中IL-21、IL-22的变化及其意义。结果子痫前期患者轻、重两组比较,血清IL-21、IL-22差异均有统计学意义（P〈0.05）;子痫前期重度组中血清IL-21水平高于子痫前期轻度组,但差异无统计学意义（P〉0.05）;子痫前期重度组中血清IL-22水平高于子痫前期轻度组,差异有统计学意义（P〈0.05）。对子痫前期患者血清中IL-21、IL-22进行Pearson相关性分析,差异无统计学意义（r=0.203,P〉0.05）。结论子痫前期患者血清IL-21、IL-22水平明显升高,提示IL-21、IL-22可能与子痫前期的发病存在一定关系,对子痫前期的诊断及治疗具有重要价值。

Objective To detect the expression of IL-21, IL-22 in serum of patients with preeclampsia and normal pregnant women, and provide a new method for diagnosing preeclampsia. Methods A total of 23 women with mild preeclampsia（mild group） and 30 women with severe preeclampsia（severe group） who admitted to the Department of Obstetrics in our hospital, were selected from April to August in 2014. 30 normal late pregnant women were selected over the same period as the control group. Enzyme-linked immune sorbent assay（ELISA） was used to detect the expression of IL-21,IL-22 in serum of these women. Results The serum level of IL-21 and IL-21 in mild group and severe group was significantly higher than the control group respectively（P〈0.05）. The serum level of IL-21 in severe group was higher than mild group, and the difference was not statistically significant（P〉0.05）. The serum level of IL-22 in severe group was higher than mild group and the difference was also statistically significant（P〈0.05）. Pearson correlation analysis results showed that there was not found a positive or negative correlation between serum IL-21 and IL-22 in preeclampsia patients. Conclusion The serum level of IL-21, IL-22 in patients with preeclampsia was increased significantly,suggesting that the serum level of IL-21, and IL-22 may have a certain relationship with the pathogenesis of preeclampsia and play an important role in the diagnosis and treatment of preeclampsia.