甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉后的临床疗效及动力学分析

Clinical efficacy and kinetics analysis of mesylate ropivacaine and ropivacaine hydrochloride epidural anesthesia

目的分析甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉后的临床疗效及动力学。方法随机选取我院2012年8月~2015年8月收治的80例择期行下腹部手术患者,依据随机数字表法分为研究组（n=40）和对照组（n=40）。研究组给予甲磺酸罗哌卡因硬膜外麻醉,对照组给予盐酸罗哌卡因硬膜外麻醉。结果研究组的HR水平显著低于对照组（P〈0.05）,MAP、Sp O_2水平均显著高于对照组（P〈0.05）,感觉阻滞、运动阻滞起效时间均显著短于对照组（P〈0.05）,阻滞时间均显著长于对照组（P〈0.05）,但两组患者术中及术后不良反应发生率22.5%（9/40）、32.5%（13/40）之间的差异无统计学意义（P〉0.05）。结论甲磺酸罗哌卡因较盐酸罗哌卡因硬膜外麻醉后的临床疗效好,血流动力学稳定。

Objective To analyze the clinical efficacy and kinetics of mesylate ropivacaine and ropivacaine hydrochloride epidural anesthesia. Methods A total of 80 cases of patients scheduled abdominal surgery in our hospital from August 2012 to August 2015 were randomly selected, these patients were divided into study group（n=40） and control group（n=40） two groups according to the random number table. The study group were given ropivacaine mesylate epidural anesthesia, while the control group were given epidural ropivacaine hydrochloride. Results The HR level of the study group was significantly lower（P〈0.05）, the MAP, Sp O2 levels were significantly higher（P〈0.05）, the sensory block, motor block onset time were significantly shorter（P〈0.05）, the blocking time was significantly longer than the control group（P〈0.05）, but the difference of the incidence of intraoperative and postoperative adverse reactions between the two groups 22.5%（9/40）, 32.5%（13/40） was not significant（P〉0.05）. Conclusion The clinical efficacy of mesylate ropivacaine epidural anesthesia is better than ropivacaine hydrochloride, the hemodynamic is more stable.