甘草地上部分化学成分研究

Chemical constituents from aerial parts of Glycyrrhiza uralensis

目的研究甘草Glycyrrhiza uralensis地上部分的化学成分。方法通过硅胶、凝胶等柱色谱及高效液相色谱技术进行分离纯化,根据理化性质和核磁数据对化合物进行结构鉴定。结果从甘草地上部分乙醇提取物中分离得到12个化合物,分别鉴定为(2S)-3′-(2-hydroxy-3-methylbut-3-enyl)-4′,5,7-trihydroxy-dihydroflavanone(1)、乔松素(2)、sigmoidin B(3)、licoflavanone(4)、6-异戊烯基柚皮素(5)、短叶松素(6)、高良姜素(7)、染料木素(8)、红车轴草素(9)、山柰酚-3-O-β-D-芸香糖苷(10)、芦丁(11)、α,α′-dihydro-3,5,3′-trihydroxy-4′-methoxy-5′-isopentenyl-stilbene(12)。结论化合物1为新化合物,命名为羟甘草黄烷酮;化合物3、6、7和9是首次从甘草属植物中分离得到。

Objective To study the chemical constituents from the aerial parts of Glycyrrhiza uralensis. Methods The compounds were isolated and purified by silica gel, Sephadex LH-20 column chromatography, and HPLC. The structures of the compounds were identified on the basis of chemical and spectral methods. Results Twelve compounds were isolated from the ethanol extract of the the the aerial parts of G. uralensis and identified as（2S）-3′-（2-hydroxy-3-methylbut-3-enyl）-4′,5,7-trihydroxy-dihydroflavanone（1）, pinocembrin（2）, sigmoidin B（3）, licoflavanone（4）, 6-prenylnaringenin（5）, pinobanksin（6）, galangin（7）, genistein（8）, pratensein（9）, kaempferol-3-O-β-D-rutinoside（10）, rutin（11）, and α,α′-dihydro-3,5,3′-trihydroxy-4′-methoxy-5′-isopentenyl-stilbene（12）. Conclusion Compound 1 is a new compound named hydroxylicoflavanone, and compounds 3, 6, 7, and 9 are isolated from this plant for the first time.