基于细胞色素P450酶的丹参代谢及其药物相互作用的研究进展

Research progress on metabolism and interaction of Salvia miltiorrhiza based on cytochrome P450s

近年来,丹参被广泛应用于心脑血管疾病的治疗,因此,丹参活性成分的体内代谢及其药物间相互作用越来越受关注。就丹参提取物、主要单体成分和丹参复方基于细胞色素P450酶(CYP450s)的代谢及药物间相互作用的研究进展进行综述,为丹参及其活性成分的应用和研究提供参考。

In recent years, the Chinese medicine Salvia miltiorrhiza has been widely used in cardiovascular and cerebrovascular diseases. So, the interaction between S. miltiorrhiza and cytochrome P450 s are focused increasingly. This review summarized the research progress on the cytochrome P450s-based metabolism and interaction of S. miltiorrhiza, including its extracts, major individuals, and S. miltiorrhiza-based formulas. It systematically summarized the information which were useful for the further applications and researches on S. miltiorrhiza and its active components.