枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停临床疗效比较研究

Clinical Curative Effect of Caffeine Citrate and Aminophylline in Premature Infants with Apnea

目的:比较枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的临床疗效。方法:以我院新生儿科2012年10月至2013年10月收治的32例呼吸暂停早产儿作为对照组,我院新生儿科2013年11月至2014年11月收治的32例呼吸暂停早产儿作为治疗组,两组患儿都在相同的基础治疗上,对照组给予氨茶碱治疗,治疗组给予枸橼酸咖啡因治疗,回顾性分析两组患儿的临床疗效,观察不良反应。结果:治疗组的临床总有效率为96.9%,高于对照组的75.0%,两组比较差异有统计学意义(P<0.05)。治疗组患儿在治疗期间无发生不良反应病例,对照组有2例患儿用药时出现烦躁、心率加快,停药后症状消失。结论:枸椽酸咖啡因治疗早产儿呼吸暂停安全,不良反应少,可作为治疗早产儿呼吸暂停的首选药物。

Objective： To observe the clinical curative effect of caffeine citrate and aminophylline in premature infants with apnea.Methods： Thirty two cases of premature infants with apnea treated in neonatal department of our hospital during October 2012 to October2013 as the control group,the other 32 cases of premature infants with apnea treated in neonatal department of our hospital during November 2013 to November 2014 as the treatment group. Based on convention therapy,the control group was given aminophylline,the treatment group was given caffeine citrate. The clinical effects were compared between the two groups. The occurrence of adverse reactions were recorded.Results： With caffeine citrate treatment,the clinical effect of treatment group was significantly better than the control group,treatment efficiency between two groups had statistical significance（ P〈0.05）. There was no adverse reaction in the treatment group,but dysphoria and heart rate increased of 2 cases in control group. Conclusion： Caffeine citrate therapy for premature infants with apnea is safety and has few adverse reaction,is the preferred drug for treatment of premature infants with apnea.