新生儿缺氧缺血性脑病早期行为干预的意义

Significance of Early Intervention to the Neonates with Hypoxic-Ischemic Encephalopathy

目的:探讨对新生儿缺氧缺血性脑病(HIE)进行早期行为干预的意义。方法:将148例HIE足月儿随机分为干预组78例和对照组70例,均给予早期综合治疗,包括药物治疗(神经节苷脂静脉滴注)、高压氧疗、人工抚触;干预组在早期综合治疗基础上同时进行早期行为干预,包括早期行为训练及水疗、婴儿操等综合训练。在患儿1、3、6、12、24月龄时对其进行智力发育和心理运动发育评估。结果:干预组患儿6月龄之后的智力发育指数(MDI)、心理运动发育指数(PDI)均高于对照组(P<0.05)。干预组后遗症(脑瘫、智能发育迟滞等)发生率为6.41%(5/78),低于对照组的15.71%(11/70)。结论:在早期综合治疗基础上对HIE患儿进行早期行为干预可明显改善患儿智力、运动发育,减少脑瘫、智能发育迟滞等后遗症的发生,改善预后。

Objective： To discuss the significance of early intervention to the neonates with hypoxic-ischemic encephalopathy（ HIE）.Methods： One hundred and forty eight neonates with HIE were divided into intervention group（ 78 case） and control group（ 70 case）.Early comprehensive treatment were applied in two groups. The mental and physical development of the children was evaluated at ages of1 th,3th,6th,12 thand 24thmonths. Results： The average scores of mental development index（ MDI） and physical development index（ PDI） in the intervention group were significantly higher than those of the control group（ P〈0.05）. The incidence of cerebral palsy（ CP） and mental retardation（ MR） in the control group were significantly higher than those of the intervention group. Conclusion：Early comprehensive treatment in the neonates with HIE can improve their mental and physical development,reduce the incidence of CP and MR,and improve their outcomes.