壮骨伸筋方结合双氯芬酸钠缓释片治疗强直性脊柱炎的临床观察

Clinical observation of the effect of Zhuanggu Shenjin Formula on ankylosing spondylitis

目的:观察壮骨伸筋方治疗强直性脊柱炎的临床疗效。方法:将64例强直性脊柱炎患者随机分为两组,每组32例,对照组口服双氯芬酸钠缓释片,治疗组采用壮骨伸筋方辅以双氯芬酸钠缓释片口服,经过8周治疗后,对两组治疗前后的各项观察指标进行比较分析。结果:对照组总有效率75.0%,治疗组总有效率90.6%,治疗组明显优于对照组(P<0.05)。两组主要症状及体征(疼痛、胸廓活动度、脊柱活动度、指地距、Schober试验)显著改善(P<0.05),治疗组优于对照组(P<0.05)。结论:壮骨伸筋方治疗强直性脊柱炎,可明显改善其症状与体征。

Objective：To observe the effect of Zhuanggu Shenjin Formula on ankylosing spondylitis.Methods：Sixtyfour patients with ankylosing spondylitis were randomly divided into the treatment group and control group,thirty-two cases per each group.The control group took diclofenac sodium sustained-release tablets by oral,and the treatment group took Zhuanggu Shenjin Formula combined with diclofenac sodium sustained-release tablets.After 8 weeks,the indicators were analyzed to compare the changes before and after treatment.Results：The total effective rate of the control group was 75.0%,while that of the treatment group was 90.6%.The total effective rate of the treatment group was superior to that of the control group（P〈0.05）.After the treatment,the main clinical symptoms and signs,include pain,change in thoracic activity,spinal activity,finger tips distance and schober test,in the treatment group and control group were significantly improved（P〈0.05）,and the treatment group was better than the control group（P〈0.05）.Conclusion：Zhuanggu Shenjin Formula could significantly improve the symptoms and signs of ankylosinq spondylitis,which would lay a favorable foundation for developing new drugs for the ankylosinq spondylitis.