重组人白介素-11治疗老年人血液肿瘤化疗后血小板减少的临床研究

Clinical Study of Recombinant Human Interleukin-11 in the Treatment of Thrombocytopenia after Chemotherapy for Hematologic Tumor in Elderly

目的:观察重组人白介素对老年人血液肿瘤化疗后血小板减少的临床疗效及药物反应。方法:70例化疗后血小板减少的患者,随机分为治疗组和对照组,治疗组在化疗第2周后注射重组人白介素-11,1.5 mg/次,1次/d,连续用药7 d,后隔日一次,用2周停药;对照组不给予重组人白介素治疗。结果:治疗组总有效率明显优于对照组,差异有统计学意义(P<0.05);治疗组主要不良反应有头身关节酸痛、发热无力、恶心呕吐、注射部位红肿疼痛。结论:重组人白介素对老年人血液肿瘤化疗后血小板减少疗效显著,且不良反应可以耐受,临床可以推广应用。

Objective：To study the clinical efficiency and side effect of homemade rh IL-11 in the treatment of thrombocytopenia caused by the chemotherapy of hematologic tumor in elderly patients.Method：Seventy patients with thrombocytopenia caused by the chemotherapy of hematologic tumor were randomly divided into the treatment group and the control group.The treatment group was given Homemade rh IL-11（1.5 mg,IH,once per day for 7 days and once every two days for 2 weeks） after two weeks of chemotherapy.The control group was given usual treatment.Result：The total effect rate in the treatment group after giving homemade rh IL-11 was better than that in the control group（P0.05）.The main side effects include article-muscle pain,fatigue,fever,sick and vomiting,injection pain,edema in the treatment group.Conclusion：Homemade rh IL-11 is effective chemotherapy-induced thrombocytopenia,its side effects is tolerance,it is worth of clinical promotion.