国产FDG模块半自动合成^(18)F-氟乙基胆碱

The Semi-automatic Synthesis of ^(18)F-fluoroethyl-choline by Domestic FDG Synthesizer

18F-氟乙基胆碱(18F-FECH)是18F-FDG的重要补充,在脑瘤转移和前列腺癌及转移的诊断方面有重要的应用价值。利用国产单次PET-FDG-TI-I CPCU型FDG合成模块,未改变硬件,通过更改试剂与耗材,半自动合成18F-FECH,并在产品收集瓶前增加C18纯化柱,减少K2.2.2杂质的含量。合成时间约30min,放化产率42.0%(未时间校正,n=5),放置6h后放化纯度>99.0%,体外稳定性良好;合成时间和产率与国内外模块结果相近。结果表明,在国产单次PET-FDG-TI-I CPCU型FDG模块上可半自动合成18F-FECH,合成效率及放化纯度较高。

As an important complementary imaging agent for 18F-FDG,18F-fluoroethylcholine（18F-FECH）has been demonstrated to be promising in brain and prostate cancer imaging.By using domestic PET-FDG-TI-I CPCU synthesizer,18F-FECH was synthesized by different reagents and consumable supplies.The C18 column was added before the product collection bottle to remove K2.2.2.The 18F-FECH was synthesized by PETFDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0%（no decay corrected,n=5）,and the radiochemical purity was still more than 99.0% after6 hours.The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purity.