摘要
通过多种色谱技术及NMR谱图分析,从我国传统民间药物东北雷公藤地上部分中共分离并鉴定了12个萜类化合物,分别为pubinernoidA(1),linarionosideA(2),linarionosideB(3),3,9-dihydroxymegastigman-5-ene(4),alangionosideJ(5),(3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(6),(+)-dehydrovomifoliol(7),(3S,5R,8R)-3,5-dihydroxymegastigma-6,7-dien-9-one(8),4(15)-eudesmen-1β,7,11-triol(9),pterodontriolB(10),triptofordinC-2(11)和(4R,5S,5aR,6S,7R,9R,9aR,10S)-7-acetoxy-6,9,10-trihydroxy-2,2,5a,9-tetramethyloctahydro-2H-3,9a-methanobenzo[b]oxepine-4,5-diyl dibenzoate(12).其中,化合物1~10为首次从东北雷公藤中分离得到.
With the adoption of chromatographic methods and spectroscopic evidences,12 terpenoids are isolated and identified from the aerial parts of Tripterygium regelii. Their structures are elucidated as pubinernoid A( 1),linarionoside A( 2),linarionoside B( 3),3,9- dihydroxymegastigman- 5- ene( 4),( 3S,5R,6S,7E)- 3,5,6- trihydroxy- 7- megastigmen- 9- one( 5),( +)- dehydrovomifoliol( 6),( 3S,5R,8R)- 3,5- dihydroxymegastigma- 6,7- dien- 9- one( 7),3,9- dihydroxymegastigman- 5- ene( 8),4( 15)- eudesmen- 1β,7,11- triol( 9),pterodontriol B( 10),triptofordin C- 2( 11) and( 4R,5S,5aR,6S,7R,9R,9aR,10S)- 7- acetoxy- 6,9,10- trihydroxy- 2,2,5a,9- tetramethyloctahydro- 2H- 3,9a- methanobenzo[b]oxepine- 4,5- diyl dibenzoate( 12),respectively. Among them,compounds 1- 10 are isolated from T. regelii for the first time.
出处
《昆明理工大学学报(自然科学版)》
CAS
2016年第1期82-87,共6页
Journal of Kunming University of Science and Technology(Natural Science)
基金
国家自然科学基金项目(21262021)
关键词
雷公藤属
东北雷公藤
化学成分
萜类
倍半萜
Tripterygium
Tripterygium regelii
chemical constituent
terpenoids
sesquiterpenoids