丙酸氟替卡松/沙美特罗干粉剂联合脱敏疗法治疗尘螨过敏性哮喘的效果

Effect of fluticasone propionate/salmeterol dry powder combined with desensitization therapy on treating allergic asthma due to dust mite

目的观察丙酸氟替卡松/沙美特罗干粉剂联合脱敏疗法治疗尘螨过敏性哮喘的临床疗效与安全性。方法选择2012年1月-2014年2月我院诊治的符合诊断标准的112例哮喘患者,根据不同治疗方法将其分为观察组（n=58）和对照组（n=54）。常规治疗后,对照组吸入丙酸氟替卡松/沙美特罗干粉剂（50μg/250μg）;观察组在此基础上加用脱敏疗法。观察两组患者治疗1年后的疗效和肺功能指标。结果观察组临床疗效、总控制率、治疗后FEV1/FVC、PEF、症状评分均优于对照组;观察组复发率低于对照组,差异有统计学意义（P〈0.05）。两组患者治疗过程中无严重不良反应。结论丙酸氟替卡松/沙美特罗联合脱敏疗法治疗过敏性哮喘效果理想,且安全性高,值得推广应用。

Objective To observe the clinical efficacy and safety of fluticasone propionate/salmeterol dry powder combined with desensitization therapy for allergic asthma due to dust mite. Methods 112 patients with asthma who were diagnosed and treated in our hospital from January 2012 to February 2014 were selected and diagnosed according to the criteria of diagnosis and treatment,and were divided into observation group（n=58） and control group（n=54）.After conventional treatment,fluticasone propionate/salmeterol dry powder（50 μg/250 μg） was inhaled in the control group,while in the observation group,on the basis of the control group,desensitization therapy was added.The efficacy and pulmonary function after one-year treatment were observed. Results The clinical efficacy,overall control rate,FEV1/FVC after treatment,peak expiratory flow（PEF）,and symptom scores was better than that in the control group respectively.Recurrence rate in the observation group was lower than that in the control group,with statistical differences（P〈0.05）.No severe adverse reaction occurred during treatment. Conclusion Dry powder of fluticasone propionate/salmeterol combining with desensitization therapy can obtain an ideal effect on treating allergic asthma in high safety,which is worthy of expansive application.