摘要
目的探讨无精子症患者睾丸活检病理分型与血清抑制素B(InhB)的关系,了解血清InhB评估睾丸生精功能状态的敏感度和特异度。方法收集2009~2013年江门市中心医院无精子症患者的睾丸活检病例,依据睾丸生殖病理标准进行诊断分型,统计各型的病例数并给予分组,同时检测血清InhB水平。结果分组情况如下,生精功能基本正常组(n=12)、生精功能低下组(n=55)、生精细胞发育不完全阻滞组(n=37)和生精细胞发育完全阻滞组(n=23)、唯支持细胞综合征组(n=36)、Klinefelter综合征组(n=2)。上述6组血清InhB水平分别为(147.83±36.75)、(71.72±13.94)、(69.19±12.59)、(65.70±11.03)、(25.17±9.95)、(18.00±2.83))pg/ml。InhB水平在生精细胞发育不完全阻滞组、生精细胞发育完全阻滞组与生精功能低下组之间及唯支持细胞综合征组与Klinefelter综合征组之间比较,差异无统计学意义(P〉0.05),其他各组间比较差异有统计学意义(P〈0.05)。结论睾丸活检是诊断无精子症的最直接方法,可直观反映生精功能受损的程度。血清InhB水平与受损程度相关,唯支持细胞综合征及Klinefelter综合征患者下降最为显著,可一定程度上反映生精功能受损的情况,也是判断无精症患者睾丸生精功能有效的诊断指标。
Objective To explore the relationship between testicular biopsy pathology classification and serum inhibin B(Inh B) of azoospermia patients,and to understand the sensibility and specificity that Inh B in evaluating testicular sperm production function. Methods Testicular biopsy cases of azoospermia patients in Jaingmen central hospital from2009 to 2013 were selected.Diagnostic classification was conducted by according to testicular reproductive pathology standard.The number of each model were counted and divided into groups.The level of serum Inh B were tested. Results Grouping were as follows:spormatogenesis function normal group(n=12),low spormatogenesis function group(n=55),sperm cells development incomplete block group(n=37),sperm cells development complete block group(n=23),sertoli cell only syndrome group(n=36) and Klinefelter syndrome group(n=2).The serum Inh B level of above 6 groups was respectively(147.83±36.75),(71.72±13.94),(69.19±12.59),(65.70±11.03),(25.17±9.95) and(18.00±2.83)pg/ml.The serum Inh B level among sperm cells development incomplete block group,sperm cells development complete block group,low spormatogenesis function group,sertoli cell only syndrome group and Klinefelter syndrome group had no obvious difference(P0.05),but had obvious difference among other groups(P〉0.05). Conclusion Testicular biopsy is the most direct way to diagnose no sperm.The degree of impaired sperm production can be intuitive reaction.The level of serum Inh B has relationship with damage degree,sertoli cell only syndrome and Klinefelter syndrome patients decrease most.It reflects the impaired sperm production on a certain extent and also diagnostic indicators to determine infertile patients with testicular sperm production function effective.
出处
《中国当代医药》
2016年第5期26-28,31,共4页
China Modern Medicine
基金
广东省江门市科技计划项目(2013019)