埃索美拉唑与奥美拉唑治疗反流性食管炎的临床效果对比

Comparison the clinical effect between esomeprazole and omeprazole in treating reflux esophagitis

目的探讨埃索美拉唑与奥美拉唑治疗反流性食管炎的临床效果,为推动消化内科的治疗发展提供理论依据。方法选取2014年1-12月我院消化内科收治的100例反流性食管炎患者为研究对象,经我院伦理委员会批准,取得患者同意条件下,将其按照治疗方法的不同分为观察组和对照组,各50例。对照组患者给予奥美拉唑药物治疗,观察组患者给予埃索美拉唑药物治疗,对比两组患者在治疗后的症状改善情况。结果观察组患者的症状改善情况以及治疗总有效率优于对照组,差异有统计学意义（P〈0.05）。结论利用埃索美拉唑治疗反流性食管炎,能明显改善患者的临床症状,提升治疗总有效率,值得推广应用。

Objective To compare the clinical effect of esomeprazole and omeprazole in treating reflux esophagitis,and to provide some theory basis for promoting the treatment development of digestive system department. Methods 100 reflux esophagitis patients of digestive system department in our hospital from January to December 2014 were selected as study object.On the condition of our hospital ethics committee approval and got patients agreement,patients were divided into observation group and control group according to different treatment method,and each group was 50 cases.Patients in control group were given omeprazole,and patients in observation group were given esomeprazole.Symptoms improved conditions after treatment in two groups were compared. Results The symptoms improved conditions and total effective rate of treatment in observation group were better than that of control group,and the difference was statistical significance（P 0.05）. Conclusion Using esomeprazole in treating reflux esophagitis can obvious improve clinical symptoms of patients and enhance treatment total effective rate. It is worth to popularize in the future.