细菌群体感应抑制剂的研究进展

Research Progress on Bacterial Quorum Sensing Inhibitors

在菌群生长过程中,细菌能不断产生化学信号分子并分泌到周围环境中,当信号分子的数量达到一定阈值时,可调控菌体相关基因的表达如生物膜的形成、生物发光等,以适应环境的变化,这种现象称为细菌群体感应(quorum sensing,QS)。细菌群体感应抑制剂(quorum sensing inhibitor,QSI)以细菌的群体感应为靶点,只针对病原菌的群体感应系统起抑制作用,并不杀死体内的正常细菌或干扰其正常生命活动,为人类提供了一种新型抗菌途径。综述了细菌群体感应信号分子的调控系统和细菌群体感应抑制剂的研究进展。

Bacteria can produce chemical signal molecules and secret them into the surrounding environment during their growth processes.When the number of signal molecules reaches to a certain threshold,the related genes expression,such as biofilm formation or bioluminescent,will be regulated,in order to adapt to such environmental changes.This phenomenon is called bacterial quorum sensing（QS）.Using bacterial quorum sensing as a target,bacterial quorum sensing inhibitors（QSI）make pathogens lose pathogenicity by blocking the expression of harmful genes,whilst do not kill the normal bacteria or interfere with the normal physiological activity of bacteria,which providing a new antibacterial way for mankind.Research progress on signal molecules regulation system of bacterial quorum sensing system and bacterial quorum sensing inhibitors are reviewed in this paper.