排石冲剂方防治输尿管镜术后双J管结石形成临床研究

Clinical Research of Paishi Granules for Preventing Calculus Formation on the Double J Tube after Ureteroscopic Surgery

目的:观察排石冲剂方防治输尿管镜术后双J管结石形成的效果。方法:将输尿管结石(湿热下注兼气阴虚型)患者120例,随机分为治疗组、对照组和空白组各40例,均行输尿管镜手术,术中放置双J管,术后治疗组予排石冲剂方口服,对照组予枸橼酸钾口服,空白组不做处理,术后1月拔管,观察双J管附壁结石形成情况及出现胃肠道反应、高钾血症的情况。结果:术后1月治疗组及对照组A级尿盐结垢病例多于空白组,C级病例少于空白组,差异均有统计学意义(P<0.05)。治疗组及对照组结石重量均小于空白组,差异有统计学意义(P<0.05)。而2组在双J管附壁结石形成的预防效果疗效相当(P>0.05)。总不良反应率治疗组为2.5%,对照组为22.5%,2组比较,差异有统计学意义(P<0.05)。结论:排石冲剂方能有效预防输尿管镜术后患者双J管附壁结石形成,并且具有较高安全性。

Objective. To observe the effect of Paishi granules on preventing the formation of calculus on the double J tube after ureteroscopic surgery. Methods： One hundred and twenty patients with ureteral calculus（downward flow of damp-heat with deficiency of both qi and yin）were selected and randomly divided into the treatment group（n=40） and the control group （n=40）, the blank group（n=40）. The double J tube was placed in ureter after ureteroscopic surgery, and after surgery Paishi granules were taken orally in the treatment group, potassium citrate in the control group, and nothing in the blank group. All double J tubes were drew out after one month post-operation. Formation of calculus on Double J tube was observed, and the number of gastrointestinal reaction and hyperkalemia were recorded. Results- One month after surgery, the number of patients with the encrustation of A level urine salt in the treatment group and control group was larger than that in the blank group, and the number of patients with the encrustation of C level in the treatment group and control group was less than that in the blank group, both of which having significant difference（P 〈 0.05）. The calculus weight of the treatment group and control group was less than that of the blank group, which having significant difference（P 〈 0.05）. Two groups had similar effect on preventing the formation of calculus on the double J tube（P 〉 0.05）. The total rate of adverse reaction of the treatment group and the control group was 22.5% and 2.5% respectively. There was a significant difference between the above rate of the two groups（P 〈 0.05）. Conclusions. The study indicates that Paishi granules was effective and safe in preventing the formation of calculus on the double J tube after ureteroscopic surgery.