摘要
目的观察大柴胡汤对重症急性胰腺炎(sever acute pancreatitis,SAP)腹腔内压的影响。方法将符合入选标准的北京中日友好医院外科重症医学科SAP患者70例,按随机数字表法分为2组各35例,常规治疗组予以西医常规治疗;大柴胡汤组在常规治疗的同时鼻饲大柴胡汤。观察急性期内2组患者腹腔内压(intra-abdominal pressure,IAP)的变化并统计腹腔高压(intra-abdominal hypertension,IAH)和腹腔间室综合征(abdominal compartment syndrome,ACS)的发生率。结果入院后2组患者IAP均有升高,但第3~7天大柴胡汤治疗组IAP水平[(13.31±4.42)rnmHg(1mmHg=0.133kPa)、(13.02±5.23)mmHg、(12.35±3.34)mmHg、(11.26±4.46)mmHg、(9.89±3.44)mmHg]明显低于常规治疗组[(16.89±5.71)mmHg、(17.52±3.37)mmHg、(16.21±2.15)mmHg、(14.57±5.56)mmHg、(12.11±1.28)mmHg](P〈0.05)。急性期内大柴胡汤治疗组IAH及ACS发生率分别为40.0%(14/35)、8.6%(3/35),均明显低于常规治疗组的80.0%(28/35)、28.6%(10/35),2组比较差异均有统计学差异(矿值分别为11.667、4.629,P值均〈0.05)。结论大柴胡汤可有效降低SAP患者IAP、IAH及ACS发生率。
Objective To observe the effects of the Dachaihu decoction on intra-abdominal pressure in severe acute pancreatitis. Methods 70 patients with SAP from China-Japan Friendship Hospital were randomly divided into two groups. 35 patients in a conventional treatment group were treated with conventional treatment of severe acute pancreatitis, and 35 patients in a Dachaihu decoction treatment group were treated with the decoction through nasogastric tube based on conventional treatment. The changes of intra-abdominal pressure and the morbidity of IAH and ACS in both groups "were observed in acute stage. Results The intra-abdominal pressure in both groups increased. But the pressure in the Dachaihu decoction treatment group (13.31 ± 4.42 mmHg, 13.02 ± 5.23 mmHg, 12.35 ± 3.34 mmHg, 11.26 ± 4.46 mmHg, 9.89 ± 3.44 mmHg) was lower than the conventional treatment group (16.89 ± 5.71 mmHg, 17.52 ± 3.37 mmHg, 16.21 ± 2.15 mmHg, 14.57 ± 5.56 mmHg, 12.11 ± 1.28 mmHg) from the third day on (P〈0.05). And the morbidity ofintra-abdominal hypertension and abdominal compartment syndrome in the Dachaihu decoction treatment group were lower than the conventional treatment group in the whole acut stage (40% vs. 8.75%).The differences between two groups were statistically significant (P〈0.05). Conclusion The Dachaihu decoction may significantly reduce the intra-abdominal pressure and the morbidity of intra-abdominal hypertension and abdominal compartment syndrome among patients with severe acute pancreatitis.
出处
《国际中医中药杂志》
2016年第2期110-113,共4页
International Journal of Traditional Chinese Medicine
关键词
胰腺炎
急性坏死性
大柴胡汤
腹腔内压
腹腔高压
腹腔间室综合征
Pancreatitis, acute necrotizing
Da Chai Hu Tang
Intra-abdominal pressure
Intra-abdominal hypertension
Abdominal compartment syndrome