肝荣汤治疗慢性乙型肝炎

Treating chronic asymptomatic HBV by Ganrong decoction

目的探讨肝荣汤治疗慢性乙型肝炎的临床疗效。方法将70例慢性乙肝患者随机分为治疗组和对照组。对照组给予常规内科治疗(包括常规保肝治疗、抗病毒治疗等),治疗组在对照组基础上,予以肝荣汤治疗,对比2组治疗效果、治疗前后肝功能及胆红素代谢调节因子变化。结果治疗组总有效率91.4%,对照组总有效率65.7%,治疗组的临床疗效高于对照组(P<0.05);2组治疗前肝功能指标无统计学意义(P>0.05),2组治疗后肝功能指标较治疗前指标均显著下降,有统计学意义(P<0.05),且治疗组较对照组肝功能指标下降明显,有统计学意义(P<0.05);治疗组的HO-1及BLVRA在治疗后较对照组高,差异有统计学意义(P<0.05)。结论肝荣汤治疗慢性乙肝具有上调HO-1及BLVRA表达,清除自由基,保护肝细胞的作用。

Objective To observe the clinical study on treating chronic asymptomatic HBV by Ganrong decoction. Methods The 70 patients with chronic asymptomatic HBV were divided into two groups randomly. The control group were treated with conventional internal medicine treatment（ including the conventional treatment of hepatoprotive and antiviral,etc） alone. The observation group was given Ganrong decoction on the basis of control group. Compared treatment effect and liver function changes of two groups before and after treatment. Results The effective rate of observation group was 91. 4%,control group was 65. 7%. Clinical curative effect of observation group was better than control group（ P〈0. 05）. There were no significant difference between the liver function of patients in two groups before treatment（ P〉0. 05）. The liver function after treatment was significantly lower than that before treatment（ P〈0. 05）. The liver function in the observation group was significantly lower than that in the control group after treatment（ P〈0. 05）. The regulatory factor such as heme oxygenase-1（ HO-1）,biliverdin reductase（ BLVRA） in the observation group was significantly higher than that in the control group after treatment（ P〈0. 05）. Conclusion Ganrong decoction may be a better therapy for treating chronic asymptomatic HBV.