T2DM合并抑郁症的相关危险因素及其与动脉硬化的关系

T2DM Related Risk Factors Associated with Depression and Its Relationship with Atherosclerosis

目的探讨2型糖尿病（T2DM）合并抑郁症的相关危险因素及其与动脉硬化的关系.方法：从本院2011年9月～2013年9月收治的T2DM合并抑郁症患者中随机选择51例设为观察组,并选择51例T2DM未合并抑郁症患者作为对照组.结果：在女性患者人数和并发症以及丧偶情况、体质指数、血糖控制等方面,两组比较,差异均有统计学意义.经多因素回归分析,女性和并发症多以及丧偶和体质指数高、血糖控制差为2型糖尿病合并抑郁症的相关危险因素（均P〈0.05）;但在年龄和病程等方面,两组经比较差异均无统计学意义（均P〉0.05）.HAMD评分与IMT、HbA1c均呈正相关关系,差异均有统计学意义（均P〈0.01）;HAMD评分与CRP无相关性,差异无统计学意义（P〉0.05）.结论：经回归分析发现,2型糖尿病合并抑郁症的相关危险因素有女性和并发症多以及丧偶和体质指数高、血糖控制差,且2型糖尿病合并抑郁症与糖尿病大血管病变和微血管病变均具有相关性,动脉硬化与抑郁症的发病过程具有相关性.

Objective: To explore the related risk factors of T2DM combined with depression and the relationship with hardening of the arteries.Methods:51 cases of patients T2DM combined with depression in our hospital from September 2011 to September 2013 were selected as the observation group,and 51 cases of patients T2DM was not associated with depression were selected as the control group.Results:The differences of female patients and the number of complications and widowed glycemic control,body mass index,etc between the two groups were all significantly(allP<0.05).By multiple factor regression analysis,female and more complications and widowed and body mass index is high,poor blood glucose control in patients with type 2 diabetes mellitus is a risk factor for depression(allP>0.05); but in the aspects of age and duration of the two groups there was no significant difference(P<0.05).The HAMD score and IMT, HbA1c were positively correlated,the differences were statistically significant,(all P<0.01); there is no relationship between HAMD score and CRP, no significant difference(P<0.05).Conclusion:The regression analysis showe that the related risk factors in type 2 diabetic patients with depression are women and many complications and widowed and body mass index is high, poor blood glucose control, and type 2 diabetes with depression and diabetic macrovascular and microvascular lesions are correlated with the pathogenesis,the correlation of hardening of the arteries and depression.