SP-D在慢性阻塞性肺疾病患者吸入噻托溴铵后的临床表达水平

Clinical Expression Level of SP-D in Patients with Chronic Obstructive Pulmonary Disease after Inhalation of Tiotropium Bromide

目的针对SP-D在慢性阻塞性肺疾病患者吸入噻托溴铵后的临床表达水平进行研究.方法：随机选择2012年12月～2015年2月期间,我院收治的慢性阻塞性肺疾病患者120例作为本次研究的对象,将其平均分为对照组和观察组.对照组患者实施常规治疗,观察组患者实施噻托溴铵吸入治疗,针对观察组和对照组患者肺功能指标、血气指标、治疗前后的SP-D指标、不良反应发生情况进行观察分析.结果：在本次研究中,观察组和对照组患者治疗前后的肺功能指标比较,有显著差异,P〈0.05,具有统计学意义.而针对治疗后的观察组和对照组患者的肺功能指标进行比较,P〈0.05,具有统计学意义.治疗前与治疗后,观察组患者与对照组患者的血气指标比较,P〈0.05,具有统计学意义.观察组患者治疗后的血气指标与对照组治疗后的血气指标进行比较,P〈0.05,具有统计学意义.观察组患者治疗后的SP-D与对照组比较,P〈0.05,具有统计学意义.观察组与对照组患者的不良反应发生率分别为5.00%、11.67%,P〉0.05,无统计学意义.结论：在慢性阻塞性肺疾病患者的治疗中,实施吸入噻托溴铵治疗,患者的肺功能指标、血气指标得到了显著的改善,且患者的SP-D指标有显著的改善.

Objective: To research SP-D in patients with chronic obstructive pulmonary disease after Inhalation of Tiotropium bromide the clinical expression level.Methods:Randomly selected during December, 2012 to February 2015, our hospital 120 cases of patients with chronic obstructive pulmonary disease as the research object,its averaged were divided into control group and observation group.Control group patients with conventional treatment,Observation group of patients implemented Tiotropium bromide inhalation therapy,in view of the observation group and control group in patients with lung function index,blood gas index,before and after treatment of SP-D index, analysis of incidence of adverse reactions were observed.Results:In this study,the observation group and control group before and after treatment in patients with lung function index compared,P<0.05,there was statistical significance.And in view of the observation group and control group after treatment in patients with lung function index compared,P<0.05,there was statistical significance.Before and after treatment, the observation group of patients compared with control group patients with blood gas index,P<0.05,there was statistical significance.Observation group of patients after treatment of blood gas index compared with the control group after treatment of blood gas index,P<0.05,there was statistical significance. Observation group of patients after treatment of SP-D compared with control group,P<0.05,there was statistical significance.The observation group and control group patients the incidence of adverse reactions respectively was 5.00%,11.67%,P>0.05,there was no statistical significance.Conclusion:In the treatment of patients with chronic obstructive pulmonary disease, the implementation of suction Tiotropium bromide treatment, the patient's lung function index, blood gas index are improved significantly, and the patient's SP-D index improved significantly.