血清α1-酸性糖蛋白水平对类风湿关节炎疗效的评价

Evaluation of Serum Alpha 1-Acid Glycoprotein in Therapeutic Efficiency of Rheumatoid Arthritis

目的探讨血清α1-酸性糖蛋白（AAG）在类风湿关节炎（RA）患者联合给药治疗前后血清中的变化，评价血清AAG检测在RA中的初步应用。方法选择2013年3月～2014年8月在西安市第五医院门诊及住院的初诊RA患者88例，给予甲氨蝶呤、柳氮磺吡啶和羟氯喹联合给药，于第0，6个月留取患者血清，用速率散射比浊法测定患者血清中AAG度类风湿因子（RF）水平，同时测定红细胞沉降率（erythrocyte sedimentation rate，ESR），并记录RA患者的疾病活动指数28（DAS28）。结果治疗后RA患者血中AAG（1136．30±322．40mg／L），RF（43．73士4．53）IU／ml，ESR（34．56±9．21mm／h）及DAS28（3．10±1．0）均有明显下降（P〈0．05或0．01），且AAG与ESR，RF及DA$28呈正相关（r=0．19，P=0．02;r=0．24，P=0．02和r=0．39，P=0．03）。结论RA患者血清中AAG随治疗明显变化，对RA的疗效有一定评价作用。

Objective To investigate serum alpha 1-acid glycoprotein （AAG） in patients with rheumatoid arthritis （RA） patients with serum drug before and after the treatment,application of evaluation of serum alpha 1-acid glycoproteindetection in RA. Methods 88 cases of newly diagnosed RA patients treated with methotrexate,hydroxychloroquine combined with pyridine and the Liu Danhuang administration,in zeroth and June. The patients were taken for determination of serum AAG and rheumatoid factor in the serum of the patients with rate nephelometry （RF） levels, and erythrocyte sedimentation rate （ESR） ,and record the patients with RA disease the activity index of 28 （DAS28）. Results After treatment,RA in the blood of patients with AAG （1 136.30±322.40 mg/L） ,RF（43. 73±4. 53 IU/ml） ,ESR （34.56±9.21 mm/h） and DAS28 （3.10± 1.0） were significantly decreased （P〈0.05 or 0, 01） ,and the AAG, ESR, RF and DAS28 were positively correlated （r=0. 19,P=0.02;r=0.24,P=0.0 and r=0.39,P〈0.03）. Conclusion The serum RA inpatients with AAG changes obviously,had certain curative effect evaluation of RA.