丁基苯酞治疗脑梗死后轻度认知障碍疗效观察

Clinical observation on the therapeutic efficacy of butylphthaiide in treating mild cognitive impairment after cerebral infarction

目的观察丁基苯酞在脑梗死后轻度认知障碍（MCI）患者中的临床疗效。方法将90例患者随机分为治疗组和对照组，治疗组给予常规药物加丁基苯酞，对照组仅用常规药物。采用简易智能状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）、中国卒中量表（CSS）及巴氏指数量表（BI）对两组患者治疗前、治疗3个月后认知和神经功能状况进行评估。结果治疗组基本治愈率为84．O％，对照组为57．5％；治疗组总有效率为98．0％，对照组为82．5％，差异均有统计学意义（P〈0．05）。与对照组比较，治疗组MMSE、CSS及BI量表评分明显增加（P〈0．01）；MoCA评分增加，差异有统计学意义（P〈0．05）。结论丁基苯酞治疗脑梗死后轻度认知障碍较为有效安全。

Objective To observe the clinical efficacy of butylphthalide in treating mild cognitive impairment （MCI）. Methods 90 patients were divided into the treatment group（ treated with conventional drugs and butylphthalide） and the control group（treated with conventional drugs）. Mini-Mental State Examination （ MMSE）, Montreal Cognitive Assessment （ MoCA）, Chinese Stroke Scale （CSS） and Barthel Index（BI） were adopted to evaluate the cognitive and neurological status of patients before the treatment and 3 months later. Results Cure rates were 84.0% in the treatment group and 57.5% in the control group. Effective rates were 98.0% in the treatment group and 82.5% in the control group. Both the differences were statistically significant（P 〈 0.05 ）. Compared with the control group,MMSE score, CSS score and BI score for the treatment group increased significantly（ P 〈 0.01 ）, MoCA score increased significantly（ P 〈 0. 05）. Conclusion Butylphthalide is effective and safe for the treatment of mild cognitive impairment after cerebral infarction.