结直肠癌患者手术前后凝血功能的变化及临床意义

Changes and clinical significance of coagulation function in colorectal cancer patients before and after surgery

目的了解结直肠癌患者手术前后凝血功能指标的变化及临床意义。方法结直肠癌患者50例,于术前3天、术后第1、7、14、30天测定血小板(PLT)、血浆纤维蛋白原(FIB)、血浆纤维蛋白原降解产物(FDP)、凝血酶-抗凝血酶复合物(TAT)、血浆纤维蛋白肽(FPA)、纤溶酶-抗纤溶酶复合物(PAP)、D-二聚体(D-D)量;对照组30例,为同期良性结直肠疾病手术者。结果与对照组比较,结直肠癌患者手术前后各检测指标值偏高,差异有统计学意义(P<0.05),术后30天上述指标与对照组比较,差异无统计学意义;结直肠癌患者术后15天与术前比较,各项指标均有不同程度的改善,差异有统计学意义(P<0.05)。结论结直肠癌患者存在明显的凝血、抗凝及纤溶机制的异常,其变化与病情发展及预后有关。

Objective To explore the changes of blood coagulation parameters in patients with colorectal cancer and their clinical significance. Methods Fifty patients with colorectal cancer were re- cruited in our hospital. The PLT, plasma FIB, plasma FDP, TAT complexes, plasma FPA, PAP complexes, and D-dimer were evaluated on the 3rd day before operation and the 1 st,7th, and 14th day after operation. Thirty patients with benign colorectal diseases received surgical treatment as controls. Result Compared with the control group, patients with colorectal cancer had higher values of blood coagulation parameters before and after surgery （P 〈 0.05 ）. For the parameters on the 30th day after operation, there were no sig- nificant differences between colorectal cancer patients and controls. For colorectal cancer patients, parame- ters on the 15th day were significantly improved compared with the preoperative data （ P 〈 0.05 ）. Con- clusion There are abnormal blood coagulation parameters in patients with colorectal cancer. The changes are closely related with the progression of patientg condition and prognosis.