CCR5与支气管哮喘免疫学发病机制研究进展

Research progress of CC chemokine receptor 5 and pathogenetic mechanism of bronchial asthma

支气管哮喘(哮喘)是儿童最常见的慢性呼吸道炎症性疾病之一,多种细胞如淋巴细胞、嗜酸性粒细胞、中性粒细胞、肥大细胞、气道上皮细胞等参与该炎症进程。研究表明,趋化因子及其受体通过对炎症细胞的募集与激活,在哮喘的发生、发展中发挥作用。CC趋化因子受体5(CCR5)具有调控T细胞和单核细胞/巨噬细胞系的迁移、增殖与免疫功能,成为哮喘发病机制的研究热点,该文对CCR5及其配体的功能和信号通路与哮喘相关的研究进展进行综述。

Bronchial asthma is one of the most common chronic airway inflammation diseases in chil- dren. Multiple cells, such as T lymphocytes, eosnophils, neutrophils, mastocyte cells and alternative cells air- way epithelial cells participate in the progression of inflammation. Previous studies have indicated that chemo- kines and their receptors play a role in the incidence and development of bronchial asthma by recruiting and activating inflammatory cells. CC chemokine receptor 5 （ CCR5 ） functions to regulate the migration, proliferation and immunity of T lymphocytes and monocytes/macrophages. CCR5 has become the focus of revealing the pathogenesis of bronchial asthma. This article reviewed the function and signaling pathway of CCR5 and their ligands, as well as their relevance with bronchial asthma.