血清F-β-hCG、雌激素及PROG在异位妊娠早期诊断中的应用

Serum F-β-hCG,estrogen and PROG detection in early diagnosis of ectopic pregnancy

目的探讨研究血清人游离β人绒毛膜促性腺激素(F—β-hCG)、雌激素及孕酮(PROG)的测定在异位妊娠早期诊断中的临床应用。方法选取绵阳市人民医院自2014年5月到2015年5月接收的40例正常妊娠孕妇以及80例异位妊娠孕妇作为研究对象,其中正常妊娠孕妇作为A组,对异位妊娠孕妇的临床资料和相关病历进行回顾性分析,将入院时仅采用通过检测血清F-β-hCG诊断异位妊娠的40例患者列入B组,将通过血清F.β—hCG、雌激素及PROG联合检测诊断的40例异位妊娠患者记为C组,对比分析两组诊断的准确率与确诊时间;同时,分别检测A组和C组孕妇的血清F—β-hCG、雌激素及PROG的含量水平,对比分析两组孕妇各指标的变化情况。结果 A组孕妇血清F-β-hCG、雌激素及PROG的含量分别为(1151.4±123.5)IU/mL、(41.2±6.3)ng/mL和(25.4±9.1)ng/mL,C组孕妇血清F-β-hCG、雌激素及PROG的含量分别为(860.4±93.4)IU/mL、(7.3±2.1)ng/mL和(5.3±3.5)ng/mL,组间相比均有显著性差异(t值分别为3.99、4.34、4.56,均P<0.05)。对B组、C组孕妇诊断的准确率分别为75.00%、97.50%,组间相比有显著性差异(X^2=4.97,P<0.05)。对B组、C组孕妇诊断的确诊时间分别为(4.1±1.03)d、(1.36±0.46)d,组间相比有显著性差异(t=4.49,P<0.05)。结论血清F—β-hCG、雌激素及PROG的测定在异位妊娠的早期诊断中具有较高的临床应用价值,其联合诊断可以明显提高诊断的灵敏度、缩短确诊的时间,减少一系列相应的不良后果,值得在临床推广。

Objective To study the clinical application of serum F-β-hCG, estrogen and progestin （ PROG） in early diagnosis of ectopic pregnancy .Methods From May 2015 to May 2014 totally 40 cases of normal pregnancy and 80 cases of ectopic pregnancy admitted in Mianyang City People ’ s Hospital were selected in the research .The cases of normal pregnancy were in group A , and clinical data and related medical history of ectopic pregnancy were retrospectively analyzed .Forty cases of ectopic pregnancy diagnosed only by serum F-β-hCG were recruited in group B , while another 40 cases diagnosed by serum F-β-hCG, estrogen and PROG were recruited in group C . Diagnosis accuracy and the time of confirmed diagnosis were compared between group B and group C .Meanwhile, serum F-β-hCG, estrogen and PROG were detected in group A and group C to compare the changes of each group .Results The serum F-β-hCG, estrogen and PROG were 1 151.4 ±123.5 IU/mL, 41.2 ±6.3ng/mL and 25.4 ±9.1ng/mL, respectively in group A and 860.4 ±93.4IU/mL, 7.3 ±2.1ng/mL and 5.3 ±3.5ng/mL, respectively in group C .The differences between two groups were significant （ t value was 3.99, 4.34 and 4.56, respectively, all P〈0.05）.Diagnostic accuracy of group B and group C was 75.00% and 97.50%, respectively, and the difference was significant （χ2 =4.97,P〈0.05）.Confirmed diagnosis time of group B and group C was 4.1 ±1.03d and 1.36 ±0.46 d, respectively with significant difference （t=4.49, P〈0.05）.Conclusion Detection of serum F-β-hCG, estrogen and PROG has high clinical value in early diagnosis of ectopic pregnancy .Joint diagnosis with them can improve diagnostic sensitivity , shorten the time of confirmed diagnosis , and reduce a series of corresponding consequences , so it is worthy of wide popularizing in clinics .