更昔洛韦治疗成人病毒性脑炎患者的疗效及其对CPR,IL-6和TNF-α的影响

Effect of ganciclovir on the level of CRP, IL-6 and TNF-α in adults with viral encephalitis and its efficacy

目的探讨更昔洛韦用于治疗成人病毒性脑炎的临床效果,不良反应和该药物对于患者脑脊液中C反应蛋白(CRP)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的影响。方法将186例本院诊断为成人病毒性脑炎患者随机分为2组:观察组93例(给予更昔洛韦治疗)和对照组93例(给予利巴韦林治疗)。2组疗程均为15 d,治疗结束后,比较2组临床疗效及不良反应情况。在治疗的第0日及第15日均分别抽取2组患者脑脊液,检测脑脊液中CRP、IL-6及TNF-α水平及其变化情况。结果观察组和对照组总有效率分别为96.8%和91.4%,差异有统计学意义(P<0.05);不良反应发生率分别为2.3%和3.2%,2组差异无统计学意义(P>0.05);与对照组相比,观察组患者脑脊液中CRP、IL-6及TNF-α改善的水平优于对照组,差异有统计学意义(P<0.05)。结论更昔洛韦用于治疗成人病毒性脑炎临床疗效确切,并能够降低相关炎性因子,改善脑部神经功能,值得临床推广使用。

Objective To observe the therapeutic efficacy and effect of ganciclovir on C reactive protein （CRP）, interleukin 6 （IL-6） and tumor necrosis factor-α（TNF-α） in adults with viral encephalitis. Methods Totally of 186 patients with viral encephalitis from January 2012 to January 2015 were randomly divided into 2 groups： 93 patients in the observation group were treated with ganciclovir, while 93 patients in the control group were treated with ribavirin. The therapeutic efficacy was observed and the levels of CRP, IL-6 and TNF-α were determined. Results The total effective rate of the observation group and the control group was 96.8% and 91.4%. The adverse reaction rate of the observation group and the control group was 2.3% and 3.2%. The levels of CRP, IL-6 and TNF-α decreased in the observation group, and the recovery of neurological function on viral encephalitis im- proved. Conclusion Early therapy of gancielovir can improve the therapeutic efficacy and obviously decrease the level of CRP, IL-6 and TNF-α on viral encephalitis.