职业枯竭与职工唾液中免疫球蛋白G的相关性分析

Correlation between job burnout and salivary immunoglobulin G in employees

目的探讨职业枯竭对职工唾液中免疫球蛋白G（IgG）浓度的影响。方法于2014年9月对186名某太阳能光伏企业职工进行职业枯竭程度评定，采用酶联免疫吸附（ELISA）试验测定其唾液中IgG浓度。结果工龄〉20年组职工IgG浓度[（53．80±8．22）μg／ml]高于≤15年组[（49．93±7．97）μg/ml]，差异有统计学意义（P〈0．05）；长白班组唾液中IgG浓度[（54．98±7．62）μg／m1]高于白夜倒班组[（51．85±7．94）μg／m]1，差异有统计学意义（P〈0．05）；人格解体阳性组的IgG浓度[（50．69±9．89）μg／ml]低于阴性组[（53．19±6．54）μg／ml]，差异有统计学意义（P〈0．05）；唾液中IgG浓度与情感耗竭、人格解体、职业枯竭评分呈负相关（r=0．194、-0．152、-0．210，均P〈0．05）。结论职业枯竭与唾液中IgG浓度呈负相关，唾液中IgG浓度可作为职业枯竭识别与评价的生物标志物。

Objective To investigate the influence of job burnout on salivary immunoglobulin G（IgG） concentration in employees. Methods In September 2014, evaluation of job burnout was performed for 186 employees in a solar photovoltaie company, and enzyme-linked immunosorbent assay was used to measure salivary IgG concentration. Results The employees with over 20 working years had a significantly higher salivary IgG concentration than those with ≤15 working years （53.80±8.22 μg/ml vs 49.93±7.97μg/ml, P〈0.05）. The employees with long-day shifts had a significantly higher salivary IgG concentration than those with day-night shifts（54.98±7.62μg/ml vs 51.85±7.94μg/ml, P〈0.05）. The employees with depersonalization had a significantly lower salivary IgG concentration than those without depersonalization （50.69±9.89 vs 53.19±6.54, P〈0.05）. The salivary IgG concentration was negatively correlated with the scores of emotional exhaustion, depersonalization, and job burnout （r =-0.194, -0.152, and -0.210, all P〈0.05）. Conclusion Job burnout is negatively correlated with salivary IgG concentration, which tends to decrease with the increasing severity of job burnout. Therefore, salivary IgG can be used as a biomarker for the identification and evaluation of job burnout.