病原相关分子模式和损伤相关分子模式在免疫炎症反应中的作用

Roles of pathogen-associated and damage-associated molecular patterns in immune inflammatory response

病原相关分子模式(PAMP)和损伤相关分子模式(DAMP)是与免疫学息息相关的两个分子。DAMP是组织或细胞受到损伤和低氧等因素刺激后释放到细胞间或血液循环中的一类物质;PAMP则是病原体上的分子结构。两者均被模式识别受体(PRR)识别引起免疫应答。目前,已经有研究表明,DAMP和PAMP与慢性炎症疾病和自身免疫性疾病有关。本文就PAMP和DAMP分子在免疫炎症反应中的作用作一综述。

Pathogen-associated molecular patterns（PAMP） and damage-associated molecular patterns（DAMP） are two molecules closely linked to immunology. DAMP are defined as a class of substances released to the cell or blood supply upon stimulation by tissue damage, cell hypoxia, or other factors. PAMP form the molecular structure of the pathogen. Both of these molecules are identified by pattern recognition receptors, which leads to the immune response. To date, research shows that DAMP and PAMP are associated with chronic inflammatory and autoimmune diseases. This thesis will summarize the roles of PAMP and DAMP molecules in immune inflammatory response