麒麟丸联合芬吗通对薄型子宫内膜厚度、血流和妊娠率的影响

Effects of Qilin pills combined with femoston on the endometrial thickness,endometrial blood flow and pregnancy rate of patients with thin endometrium

目的:观察麒麟丸联合芬吗通对薄型子宫内膜厚度及类型、血流和妊娠率的临床疗效。方法:前瞻性研究76例薄型子宫内膜不孕患者,随机分为对照组和研究组各38例,对照组经阴道给予芬吗通,研究组在对照组的基础上联合口服麒麟丸进行治疗。比较对照组和研究组治疗3个周期后子宫内膜厚度、类型、血流、血雌激素(E2)浓度情况和治疗半年后的自然妊娠率。结果:对照组和研究组治疗3个周期后的子宫内膜厚度、类型、血流、E2浓度情况均有明显改善(P<0.05),且研究组子宫内膜厚度和血流优于对照组,差异均有统计学意义(P<0.05);治疗半年后自然妊娠率研究组显著高于对照组(52.6%vs 28.9%),差异有统计学意义(P<0.05);研究组和对照组中妊娠患者子宫内膜厚度、类型、血流分别与本组中未妊娠患者比较,差异均有统计学意义(P<0.05)。结论:麒麟丸联合芬吗通治疗因子宫内膜薄而致的不孕,可有效改善子宫内膜厚度及血流,提高治疗半年后的自然妊娠率。

Objective： To study the clinical effects of Qilin pills combined with femoston on the endometrial thickness, type and blood flow, and pregnancy rate of thin endometrium patients. Methods： A total of 76 patients with thin endometrium were equally assigned into study group and control group who were treated with Qilin pills combined with femoston and femoston alone, respectively, both for a course of three menstrual cycles. The endometrial thickness, type, blood flow, serum estradiol （E2） levels, and natural pregnancy rates of two groups after treatment were compared. Results： The endometrial thickness, type, blood flow and serum E2 levels of two groups after treatment were significantly improved as compared with these before treatment （P〈0.05）. Furthermore, the endometrial thickness and blood flow were significantly different between the two groups after treatment （P〈0.05）. Half a year after treatment, the natural pregnancy rate in study group was significantly increased compared with control group （52.6% vs 28.9%, P〈0.05）. Moreover, the endometrial thickness, type and blood flow were significantly different between pregnancy and unpregnancy in both groups （P〈0.05）. Conclusion： Qilin pills combined with femoston can effectively improve the endometrial thickness and blood flow, and significantly enhance the natural pregnancy rates in patients with thin endometrium.