博洛尼亚标准卵巢低反应者IVF/ICSI妊娠结局的预测因子

Predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation IVF

目的:探讨根据博洛尼亚标准诊断的卵巢低反应(POR)患者体外受精(IVF)/卵胞质内单精子注射(ICSI)临床妊娠结局的预测因子。方法:回顾性分析392名符合博洛尼亚标准的POR患者的临床资料。采用多因素逻辑回归分析法研究这些POR患者IVF/ICSI-ET的临床妊娠结局的预测因子。结果:女方年龄、移植胚胎数和促排卵方案是POR患者IVF临床妊娠结局的预测因子,其中女方年龄是最佳的预测因子。结论:随着女方年龄的增加,妊娠率会不断下降。因此,应该鼓励博洛尼亚标准POR患者积极接受IVF-ET助孕。生长激素、ICSI或辅助孵化均不能明显改善POR患者的IVF临床妊娠结局。

Objective： To explore the predictive factors for clinical pregnancies of poor ovarian responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization （IVF）. Methods： The present study included 392 poor ovarian responders diagnosed according to the Bologna criteria （392 first poor response cycles and 247 subsequent conventional stimulation cycles） in our IVF center. Binary logistic regression analysis was used to study the association between possible predictive factors and clinical pregnancy of poor responders in ovarian stimulation IVF. Results： The significantly predictive factors for clinical pregnancies of poor responders in ovarian stimulation IVF were female age, number of embryos transferred and ovarian stimulation protocol. Female age had the best predictive value for clinical pregnancy of poor ovarian responders. Conclusion： Poor ovarian responders should be encouraged to attempt further ovarian stimulation IVF treatment as soon as possible because the pregnancy rate decreases with advancing female age. Growth hormone supplementation, ICSI procedure or assisted hatching seem not be able to prominently improve the pregnancy outcomes of poor responders diagnosed according to the Bologna criteria in ovarian stimulation IVF.