多烯磷脂酰胆碱对酒精性脂肪肝患者的临床疗效研究

Polyene phosphatidylchofine for patients with alcoholic fatty liver

目的探讨多烯磷脂酰胆碱对酒精性脂肪肝患者的临床疗效。方法回顾性分析本院2014年1月至2015年2月收治的84例酒精性脂肪肝患者的临床资料，对照组42例患者采用常规治疗，而观察组42例患者在常规治疗基础上加用多烯磷脂酰胆碱，比较两组患者的治疗效果。结果两组患者进行治疗后，观察组的肝病改善情况（94．16％）显著优于对照组（P〈0．05），且肝功能和血脂等指标，好转情况亦优于对照组（P〈0．05），组间差异均具有统计学意义；两组患者治疗后，观察组的肝功能指标TBIL（15．8±4．3）μmol／L、AST（24．5±15．1）U／L、ALP（113．7±27．3）U／L、ALT（39．5±10．3）U／L、1-GT（32．8±10．6）U／L，同对照组相比，有显著改善，且组间差异有统计学意义（P〈0．05）；两组患者治疗后，观察组的血脂水平TC（5．02±1．04）mmol／L、TG（1．76±0．73）mmol/L、LDL—C（2．88±0．86）mmol/L、HDL—C（1．28±0．25）mmol／L，同对照组相比，明显好转，且组间差异有统计学意义（P〈0．05）。结论多烯磷脂酰胆碱可有效改善酒精性脂肪肝患者的临床症状，保护患者的肝脏功能，从而促进患者病情改善，值得临床应用。

Objective To investigate the efficacy of polyene phosphatidylcholine for patients with alcoholic fatty liver. Methods 84 patients with alcoholic fatty liver treated at pur hospital from January, 2014 to February, 2015 were included into this study and divided into a control group and an observation group, 42 for each group. The control group were treated with conventional therapy; and in addition, the observation group were treated with polyene phosphatidylcholine. The treatment efficacies were compared between these two groups. Results After the treatment, the improved rate of liver disease in the observation group was 94.16%, which was significantly better than that inthe control group （P〈0.05）; the liver function,blood lipids, and other indicators were better in the observation group than in the control group （P 〈0.05 ）, with statistical differences（P〈0.05）; the levels of TBIL, AST, ALP, ALT, y-GT, TC, TG, LDL-C, and HDL-C in the observation group were（15.8±4.3）umol/L,（24.5± 15.1 ）U/L,（ 113.7 ± 27.3）U/L,（39.5 ± 10.3）U/L,（32.8±10.6）U/L,（5.02±1.04） mmol/L,（1.76±0.73）mmol/L,（2.88 ±0.86）mmol/L, and（1.28±0.25）mmol/L, respectively, which were better than those in the control group, with statistical differences （P〈0.05）. Conclusions Polyene phosphatidylcholine can effectively improve the clinical symptoms of patients with alcoholic fatty liver disease and protect the patients＇ liver function so as to improve the patients＇ condition. It is worth for clinical application.