职业性铝暴露与认知功能障碍的关系研究

Study of relationship between occupational aluminum exposure and cognitive disorder

目的分析职业性铝暴露与人群认知功能的关系。方法从广西某大型铝厂抽取280名接触铝粉尘男性工人为暴露组,同时在该企业抽取未接触过职业性铝粉尘,且年龄、工龄和文化程度基本相同的301名工人作为对照组。采用简易智力状态量表（MMSE）对研究对象进行认知功能评估。结果暴露组人群认知功能障碍者检出率为10.71%,非暴露组人群认知功能障碍者检出率为1.00%,两组人群认知功能障碍检出率差异有统计学意义（χ~2=25.57,P〈0.001）,暴露组人群认知功能障碍检出率高于对照组。结论职业性铝暴露可能会增加认知功能障发生风险。

Objective To investigate the effects of occupational aluminum exposure on cognitive function of workers. Methods A total of 280 male aluminum dust-exposed workers from a large aluminum plant in Guangxi were selected as subjects of the exposure group and 301 workers from the same aluminum plant whose ages, working age and education levels matched those subjects of the exposure group were selected as controls. The cognitive function was evaluated by using the mini-mental state examination （MMSE）. Results By statistics analysis we found there were 10.71% occupational persons suffered with cognitive impairment among people of the exposure group. There were 1.00% persons suffered with cognitive impairment among people of the control group. Comparison of detection rate of cognitive disorder showed that there was statistically significant difference between the two groups （χ2 =25.57, P 〈0. 001）. The detection rate of cognitive impairment of the exposure group was significantly higher than that of the control group. Conclusion Occupational alumi- num exposure can add the risks of incidence rate of cognitive impairment.