2012～2014年我院铜绿假单胞菌的耐药性监测

Analysis of drug resistance of Pseudomonas aeruginosa in our hospital 2012～2014

目的了解铜绿假单胞菌在我院的分布及其耐药性的动态变迁,以指导临床合理应用抗菌药物。方法对2012~2014年我院临床分离的988株铜绿假单胞菌的检出率及耐药率进行连续监测;采用WHO细菌耐药性监测网提供的WHONET5软件进行数据统计分析。结果 2012年共检出铜绿假单胞菌281株,2013年351株,2014年356株,分别占阴性杆菌的18.07%、18.42%、17.16%;耐药率〈20%的抗生素有氨基糖苷类、喹诺酮类、头孢吡肟、头孢他啶、亚胺培南、哌拉西林/他唑巴坦,耐药率〉30%的抗生素有哌拉西林、氨曲南及头孢曲松。结论铜绿假单胞菌是医院感染常见的致病菌,对多种抗菌药物均产生不同程度的耐药性,临床医师应根据各科的耐药率监测情况合理用药。

Objective To dynamically monitor the antibiotic resistance and distribution of Pseudomonasaeruginosa in our hospital so as to provide guidance for reasonable clinical use of antibiotics. Methods Thedrug resistance rates and detection rates of 988 strains of Pseudomonas aeruginosa isolated from clinical speci- mens from 2012 to 2014 were monitored continuously. The data were statistically analyzed by using WHONET5 software. Results The detection rate of Pseudomonas aeruginosa to gram-negative bacillus was 18.07%（281 strains） in 2012, 18.42% （351 strains） in 2013, and 17.16% （356 strains） in 2014. The drug resistance rates 〈20% were quinolones, cefepime, ceftazidime, imipenem, piperacillin/tazobactam and aminoglycosides,and the drug resistance rates 〉 30% were piperacillin, aztreonam and ceftriaxone. Conclusion The Pseudomonas aeruginosa strain is a common pathogen in hospital infection and varies in the drug resistance to manyantibiotics. Conclusion should rationally use antimicrobial agents according to the surveillance results in eachdepartment.